The aim of the course is to teach students about information technologies used in information systems of entrepreneurial companies as well as about important features and functioning modes of information systems in an enterprise. We discuss the development of integral information system, of Supply Chain Management system, of Customer Relationship Management system and of Knowledge Management system. By using different tools we follow flow of data and processes through information systems. Students are not expected to design or program parts of information systems, but to recognize basic models of data and processes, possibilities to evaluate their advantages and disadvantages, as well as possibilities of managing information collected in the information system that can be useful for making business decisions.